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Van Ness Corridor Emerges as San Francisco’s Premier Medical Destination

The Hoyt Organization

The Van Ness corridor has become one of San Francisco’s most dynamic medical and healthcare destination, anchored by the world-class Sutter Health’s California Pacific Medical Center and supported by an expanding ecosystem of medical office spaces and care providers. A highlight of this transformation is the 45,000 square feet of premium medical office space currently available at 939 Ellis St., making it the largest contiguous medical space on the market in San Francisco today. Strategically located just steps away from Sutter’s Van Ness campus, 939 Ellis offers an unparalleled opportunity for medical groups, specialty clinics, and healthcare innovators looking to establish a presence in the city’s fastest-growing healthcare hub. Ellis’ central location provides convenience for patients commuting from East Bay, the Peninsula, and Marin County. Connectivity to the Van Ness Corridor has never been better with the 2022 launch of the Van Ness Bus Rapid Transit, a 1.96-mile route running north-south featuring dedicated center bus lanes and nine stations. “The synergy between the neighborhood’s thriving healthcare community and access to transportation is reshaping the Van Ness corridor into a one-stop destination for high-quality patient care,” said Kurt Hackett, Vice President of Asset Management with Rethink Healthcare Real Estate, a private investment group that owns 939 Ellis St. “Whether it’s primary care, outpatient specialties, diagnostics, or wellness services, everything patients and providers need is increasingly concentrated in this central, transit oriented neighborhood.” The building, which is already about half occupied by Kaiser Permanente, comes to market amid a notable resurgence in San Francisco’s economy as the city positions itself for a boom in AI investments. The increase in business is being further fueled by the return-to-office trend and a growing belief that San Francisco is on the right track, according to recent surveys. Recently elected Mayor Daniel Lurie has spearheaded many new efforts that are working to bring businesses and visitors back to the world class downtown. As demand for centrally located, modern medical space continues to rise, the Van Ness corridor stands out as a focus for San Francisco’s healthcare future. “We could not be more bullish on this location,” said Jonathan Winer, President of Rethink Healthcare Real Estate. “Not only is San Francisco’s reemergence as a hotbed of business activity a catalyst for those looking to treat patients locally, but the ease of transit has made the Van Ness Corridor a convenient destination for doctors and patients, alike, who are coming from the outskirts of the city or the suburbs.” 939 Ellis St. offers flexible, build-ready medical office suites that can accommodate a range of specialties. It boasts a scenic rooftop terrace and available parking. For leasing inquiries at 939 Ellis St., contact Trask Leonard, president and CEO of Bayside Realty Partners at tleonard@baysiderp.com or Caroline Doyle, senior vice president of Bayside Realty Partners, at cdoyle@baysiderp.com. Contact Details The Hoyt Organization Andrew King +1 914-513-6895 aking@hoytorg.com Company Website https://rethink-capital.com/healthcare-real-estate/

April 23, 2025 10:20 AM Pacific Daylight Time

Silexion Therapeutics Collaborates with Multi Billion Dollar Clinical Development Player, Advancing Revolutionary Cancer Treatment Toward Clinical Trials

Global Markets News

Silexion Therapeutics' (NASDAQ: SLXN) * groundbreaking RNAi therapy showing 70-80% tumor reduction takes major step forward with global manufacturing collaboration; Wall Street analysts reportedly maintain $5 price target representing potential 500% upside as company targets $470B precision medicine market Game-Changing Partnership Announcement In a strategic move that significantly advances its revolutionary cancer treatment pipeline, Silexion Therapeutics (NASDAQ: SLXN) announced today a collaboration with global therapeutics giant Catalent to optimize and manufacture its breakthrough KRAS-targeting therapy SIL204. This partnership represents a critical acceleration toward human clinical trials, expected to begin in the first half of 2026. The collaboration will leverage Catalent's state-of-the-art Limoges, France facility—a European center of excellence for complex biologics formulation—to optimize both systemic and intratumoral delivery formulations of SIL204, supporting Silexion's innovative dual-route strategy targeting both primary tumors and metastases. "Our collaboration with Catalent represents a significant advancement in our SIL204 development program," said Ilan Hadar, Chairman and CEO of Silexion Therapeutics. "Catalent's expertise in complex formulation development will be instrumental as we work toward our goal of initiating human clinical trials in the first half of 2026." Disrupting the "Undruggable": Silexion's Breakthrough Approach to KRAS Mutations Silexion's technology stands at the frontier of precision oncology, targeting KRAS mutations—long considered the "holy grail" of cancer targets and present in over 90% of pancreatic cancers. While competitors have developed small molecule inhibitors that target only specific KRAS mutations (primarily G12C, found in just 1-2% of pancreatic cancers), Silexion's RNA interference approach silences multiple KRAS mutations at the genetic level. Recent preclinical data revealed SIL204's remarkable efficacy across multiple pancreatic cancer models: 70% reduction in tumor burden in AsPC-1 models (KRAS G12D mutation) Significant dose-dependent tumor reduction in Panc-1 models (KRAS G12D mutation) 80% tumor reduction in BxPC-3 models Most critically, for the first time, Silexion demonstrated SIL204's ability to reduce metastatic spread to secondary organs—a game-changing advancement that could transform treatment paradigms for aggressive pancreatic cancer. Dual-Route Strategy: A Comprehensive Attack on Cancer Silexion recently unveiled its expanded development plan for SIL204, integrating both systemic administration for targeting metastatic progression and intratumoral delivery for attacking primary tumors—a comprehensive approach unique in KRAS-targeted therapies. The orthotopic models used in Silexion's breakthrough studies better represent human pancreatic cancer biology by allowing tumors to develop in their native environment. This stands in contrast to subcutaneous xenograft models, where tumors grow beneath the skin rather than in the organ of origin. This expanded approach is supported by SIL204's demonstrated ability to maintain therapeutic levels for over 56 days from a single administration—an unprecedented achievement in RNAi therapeutics. Massive Market Opportunity in Precision Oncology The partnership with Catalent positions Silexion advantageously within the rapidly growing precision medicine market, projected to surge from $102 billion in 2024 to $470 billion by 2034, growing at a CAGR of 16.5%. Within this broader market, KRAS-driven cancers represent a substantial unmet need, with the market for KRAS inhibitors expected to grow at an impressive 36% CAGR, reaching $10 billion by 2032. Recent years have seen unprecedented consolidation in precision oncology, with big pharma aggressively seeking innovative assets: Pfizer's landmark $43 billion acquisition of Seagen in 2023 AbbVie's $10.1 billion purchase of Immunogen Numerous other multi-billion dollar transactions for targeted oncology assets With major pharmaceutical companies collectively holding over $170 billion in cash reserves, according to reports, the M&A environment remains highly favorable for innovative companies developing breakthrough cancer therapeutics. Wall Street's Bullish Outlook: Over 500% Potential Upside Wall Street analysts appear to recognize Silexion's potential, with Maxim Group maintaining a Buy rating and a $5 price target—representing a remarkable premium of over ~500% from today's pre market price. This seemingly bullish stance reflects confidence in Silexion's differentiated technology, promising preclinical data, and clear strategic roadmap. Silexion's partnership with Catalent adds credibility to its development roadmap, which includes toxicology and pharmacodynamic studies throughout 2025, regulatory submissions to the Israel Ministry of Health in H2 2025 and the European Union in H1 2026, and the initiation of human clinical trials in 2026. A Potential Industry Game-Changer to Watch Silexion Therapeutics stands at a pivotal moment in its development journey. With groundbreaking preclinical data demonstrating efficacy against both primary tumors and metastases, a clear strategic roadmap to clinical trials, and now a global manufacturing partnership with Catalent, the company is positioned at the intersection of high unmet medical need and significant market opportunity. As pancreatic cancer remains one of the deadliest malignancies with a dismal five-year survival rate below 13%, Silexion's innovative approach targeting multiple KRAS mutations could represent a transformative advancement in treatment paradigms—potentially reshaping the landscape for one of oncology's most challenging diseases. For investors seeking exposure to next-generation precision oncology, Silexion represents a unique opportunity to participate in the development of a potentially disruptive technology addressing one of medicine's most significant challenges. News Highlights from Silexion: - Silexion Therapeutics Announces Collaboration with Global Therapeutics Leader Catalent on Advanced siRNA Formulation Development & Clinical Manufacturing Activities - Silexion Therapeutics Unveils Innovative Expanded Development Plan for SIL204 Based on Recent Groundbreaking Preclinical Data - Silexion Therapeutics Reports Groundbreaking Positive Initial Data from Systemic Administration of SIL204 in Orthotopic Pancreatic Cancer Models *Disclaimer: This article was written and published by Wall Street Wire™, a promotional content and distribution brand and network. Nothing in this article constitutes financial or investment advice, nor does it represent an offer to buy or sell securities. The operators of Wall Street Wire network are not registered brokers, dealers, or investment advisers. This article contains and is a form of paid promotional content related to Silexion Therapeutics and was produced as part of their paid subscription to Wall Street Wire. This article has not been reviewed or approved by Silexion Therapeutics prior to publication. The information in this article is based on publicly available news reports and filings which have not been independently verified by us. Please review the full disclaimers and compensation disclosures here: redditwire.com/terms. Contact Details Wall Street Wire | Coverage Desk media.globalmarkets@gmail.com

April 23, 2025 09:54 AM Eastern Daylight Time

BioLumic Oversubscribed Funding Round Accelerates a New Category of Non-GMO Seed Traits

BioLumic

BioLumic Inc., a pioneer in seed trait innovation, today announced the close of its oversubscribed Series B Extension, securing $8.3 million USD from new and existing investors, including Ki Tua Fund, Azolla Ventures, and iSelect Fund. The new capital will accelerate the commercial growth of a breakthrough category of seed traits – xTraits™ – the world’s first seed traits activated purely by precise light signals. The round attracted a strategic investor group led by the Ki Tua Fund—an early-stage venture fund backed by global dairy leader Fonterra—alongside Azolla Ventures, a climate-focused agtech investor, and iSelect Fund, a U.S.-based food, agriculture, and healthcare innovation fund. They join existing backers DYDX Capital, Rabo Ventures, AgriZero, MIG Angels, Icehouse Ventures, and OurCrowd, underscoring broad industry validation and global reach. BioLumic is advancing high-value traits in corn, rice, soybean, and forage grasses for pasture-based dairy systems. The company’s xTraits™ technology enables seed company partners to deliver enhanced, non-GMO and non-GE traits up to 90% faster and more cost-effectively than traditional methods—unlocking new value across the agricultural supply chain. The proprietary xTraits™ platform uses targeted UV light signals to program genetic expression in plants—without altering their DNA and without the regulatory hurdles of genetic modification. This new class of seed traits significantly improves yield, stress resilience, and nutritional composition; stacks with existing biotech traits; and dramatically reduces the time, cost, and risk of trait development. “Seed traits are powerful and essential, but the innovation cycle is broken. Developing new traits takes too much time and capital to keep pace with market demand — creating tremendous risk for both seed companies and farmers,” said Steve Sibulkin, CEO of BioLumic. “The xTraits™ platform dramatically shortens the discovery-to-market timeline while stacking on top of existing varieties and trait packages. It’s a breakthrough solution to close the gap and meet urgent demand.” The funding will accelerate the rollout of its corn, soybean, rice, and forage grass traits—with a goal of capturing 10% of the non-transgenic seed trait market within five years. xTrait Platform Improves Productivity, Nutrition and Sustainability in Key Food Crops In 2025, BioLumic launched its first commercial xTraits Activation System at Gro Alliance’s seed production facility, enabling partners to integrate xTraits into elite corn inbreds and hybrids. Field trials have shown light-activated hybrid corn achieved over 20% yield gains, building on 8% gains in activated inbred parent lines. These hybrid traits will be commercially deployed in the U.S. market for the 2026 planting season. More than 10 additional traits are currently in development across multiple crops. BioLumic is also accelerating development of forage grass traits, representing a major opportunity to improve profitability and sustainability in pasture-based systems. These traits aim to boost pasture productivity and energy density—helping producers increase milk output, reduce supplemental feed use, and improve sustainability outcomes. Komal Mistry-Mehta, Ki Tua Fund Director and Fonterra’s Chief Innovation and Brand Officer, emphasized the potential of this partnership and value to NZ Inc: “Ki Tua Fund is focused on supporting startups that span Fonterra's value chain from on-farm productivity, manufacturing optimisation through to the future of food and health technologies. We know our dairy farmers need innovative solutions to increase profitability, and BioLumic's technology represents a potential game changer. In future, it could help Fonterra, and by extension NZ Inc, boost milk solids to manufacture into high value Ingredients and Foodservice exports.” These benefits are part of a broader push to align agricultural productivity with climate-smart practices. “BioLumic is creating a new category of seed traits that could help drive agricultural methane-reduction strategies, or what we call ‘Methane Moonshots’, like reducing the need for rice paddy flooding and changing the composition of pasture grass to cut enteric fermentation,” said Johanna Wolfson, General Partner at Azolla Ventures. “BioLumic delivers real-world climate advantages and economic value for farmers to create truly sustainable impact.” With fresh funding and strong commercial momentum, BioLumic is advancing a new generation of non-GMO trait innovation—scaling high-performing, sustainable traits that meet the needs of farmers, seed companies, and the global food system. About BioLumic: Founded in 2013, BioLumic is a U.S.- and New Zealand-based agricultural biotechnology company using light signaling as a programming language for plants. Its patented xTraits™ technology unlocks non-GMO genetic expression traits to enhance yield, composition, and crop resilience through a one-time, light-based seed application. BioLumic traits are scalable, fast to develop, and easily integrated into existing seed systems. Learn mores at www.biolumic.com or contact info@biolumic.com. Contact Details AgTech PR for BioLumic Jennifer Goldston jennifer@agtechpr.com Company Website https://www.biolumic.com

April 22, 2025 12:00 PM Central Daylight Time

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Centre for Neuro Skills Named to Newsweek’s America's Greatest Midsize Workplaces 2025

Centre for Neuro Skills

Newsweek named Centre for Neuro Skills (CNS), a leading provider of post-acute brain injury and stroke rehabilitation services, one of America’s Greatest Midsize Workplaces for 2025. CNS is the only neurorehabilitation provider listed in the healthcare category, achieving a 5-star rating. “We are incredibly honored to receive this recognition from Newsweek,” said David Harrington, president and CEO of CNS. “At Centre for Neuro Skills, we believe a great workplace not only is built on trust, respect and a shared commitment to growth but also fosters an environment where every employee can thrive, contribute and feel valued. This recognition is a testament to the power of our collective team’s dedication, collaboration and passion.” To determine award recipients, Newsweek partnered with Plant-A Insights to analyze more than 3.5 million online employee reviews and public data for 9,000 companies employing 500-1,000 individuals. A third-party data provider, Aniline, then leveraged its database of more than 120 key performance indicators, including leadership, integrity, compensation, career development, culture and belonging and work-life balance, to gain a comprehensive view of workplace performance and satisfaction for U.S.-based companies. CNS, with seven locations across California and Texas, recently announced a new location – its fifth in Texas – opening in late 2025 in Plano. The new clinic at 1640 Dallas Parkway Suite 3000 will include the full set of CNS services, including programs for vision, neurobehavior, cognitive retraining, speech, physical and occupational therapy with certified, highly trained clinical therapy staff. It will also feature advanced care technology, such as the ZeroG® Gait and Balance System and a Bioness Integrated Therapy System to aid in vision, motor and balance training. Focused on patient-tailored care and maximizing patient outcomes, CNS offers residential inpatient, day treatment, telerehabilitation and continued care programs to help patients regain independence through community reintegration and life skills building. Learn more about CNS’ programs here. *** About Centre for Neuro Skills Centre for Neuro Skills is an experienced and respected world leader in providing intensive rehabilitation and medical programs for those recovering from all types of brain injury. Recognized as one of America's Greatest Midsize Workplaces 2025 by Newsweek, CNS covers a full spectrum of advanced care from residential and assisted living to outpatient/day treatment. Founded by Dr. Mark Ashley in 1980, CNS has seven locations in California and Texas. For moreinformation about Centre for Neuro Skills, visit neuroskills.com, Facebook, Twitter, LinkedIn, YouTube. For a video overview of CNS, visit our YouTube channel. Media, please note: To request an interview with CNS leadership or clinical staff, please contact Robin Carr at 415.766.0927 or CNS@landispr.com. ### Contact Details Robin Carr +1 415-766-0927 cns@landispr.com Company Website https://www.neuroskills.com/

April 02, 2025 08:01 AM Pacific Daylight Time

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Stem Cell Innovators: 4 Companies Advancing Regenerative Medicine

ADIA FATE MESO CRSP

Stem cells have a unique ability—they can transform into different types of cells, making them a game-changer in regenerative medicine. From repairing heart tissue after a heart attack to potentially reversing neurodegenerative diseases like Alzheimer's, the possibilities are vast. While their potential has been known for years, challenges such as immune rejection and difficulty in controlling cell differentiation have slowed progress. However, advances in DNA and RNA research have given scientists better control over the process, opening the door to real-world treatments. The stem cell industry is now shifting from theoretical breakthroughs to tangible medical applications. In 2024, the global stem cell market was valued at $15.1 billion and is projected to grow at an annual rate of 11.41% through 2030. This surge is driven by increased research, growing demand for stem cell banking, and major strides in precision medicine. Now, let's take a closer look at a few stocks making waves in this sector. ADIA Nutrition Inc. (OTC Pink: ADIA) is quickly becoming a company to watch in the stem cell and regenerative medicine space. The company operates through two main divisions: a nutritional supplement business and its medical division, Adia Med, which is focused on advanced stem cell therapies. ADIA’s recent announcements and strong growth trajectory suggest the company is positioning itself as a leader in this high-potential sector. One of the company's standout moves is its commitment to expanding stem cell treatments across the United States. In January 2025, ADIA opened its flagship clinic in Winter Park, Florida, where it already offers treatments using umbilical cord stem cells (UCB-SC) to address conditions like Multiple Sclerosis, orthopedic injuries, and joint pain. The clinic exceeded financial expectations in its first month, covering all startup costs and proving that there is strong demand for its therapies. This success set the stage for further growth, including the opening of satellite locations across the country. ADIA’s medical division, Adia Med, is also making waves with its decision to offer Therapeutic Plasma Exchange (TPE) at all future full-service clinic locations. TPE, which removes harmful substances from a patient's blood, is being used to treat a variety of conditions, including Alzheimer’s disease. This is a major move in a rapidly growing field. According to ADIA’s CEO, Larry Powalisz, “Our current location is already delivering this therapy, and as we grow, every new full clinic equipped with top-tier apheresis machines will expand access to this innovative care.” This technology sets ADIA apart from other players in the field and positions the company to lead in advanced treatment options for patients with neurodegenerative diseases. Another area where ADIA is taking a leadership role is in the standardization of stem cell treatments. The company is working on setting new quality and safety standards for umbilical cord stem cell use in the United States. With many clinics offering subpar or non-viable stem cells, ADIA is aiming to make sure every patient gets stem cells that are live and effective. As CEO Larry Powalisz stated, “We’re crafting a movement for reliability and excellence.” The company plans to present its standards to the FDA and the Department of Health and Human Services, pushing for nationwide regulations that could transform the entire stem cell industry. On top of that, ADIA is preparing to expand internationally, as multiple overseas organizations have expressed interest in licensing the company’s treatments. The company is already in the process of reviewing the legal and regulatory steps required to bring its innovative therapies, like its flagship Adia Vita stem cell product, to other markets. ADIA’s international expansion could help it tap into a global market for regenerative medicine, offering the company even more room to grow. Lastly, ADIA’s asset-light expansion model is another key factor driving its growth. In March 2025, the company opened its first satellite clinic in Tinton Falls, New Jersey, in partnership with Keep Glowing Medical Spa and Dr. Michael Ellis. This shared space partnership allows ADIA to expand quickly without the overhead costs of building new clinics from the ground up. The Tinton Falls location will offer ADIA’s stem cell therapies, including Adia Vita and AdiaLink, to patients seeking advanced treatments for a variety of conditions. ADIA Nutrition’s combination of strong financial performance, strategic partnerships, and commitment to innovative treatments makes it an exciting stock to watch in the stem cell space. With its focus on quality, expanding treatment options, and international growth, ADIA is positioning itself to be a leader in regenerative medicine. Investors looking for a company with significant growth potential in this booming sector should keep an eye on ADIA as it continues to expand and evolve. Fate Therapeutics (NASDAQ: FATE) is a clinical-stage biopharmaceutical company that is making strides in developing stem cell therapies for both cancer and autoimmune diseases. The company's approach is built around induced pluripotent stem cells (iPSCs), which can be used to create cell therapies that are ready to be used right off the shelf. This eliminates some of the challenges of traditional stem cell treatments, which require personalized, patient-specific cells. By creating universal, off-the-shelf therapies, Fate aims to make stem cell treatments more accessible and cost-effective. One of the most promising candidates in Fate’s pipeline is FT819, a type of CAR T-cell therapy designed to treat autoimmune diseases, particularly systemic lupus erythematosus (SLE). FT819 is especially notable because it doesn’t require the usual chemotherapy conditioning that other CAR T-cell therapies do. Early trials of FT819 have shown strong potential. The first three patients treated with FT819 experienced no dose-limiting toxicities, and one patient even went into remission after the treatment. Bob Valamehr, Fate’s President of Research and Development, expressed his excitement over the results, saying, “We are pleased with the early clinical data, which continues to support the potential for disease transformation.” In addition, the FDA has allowed Fate to expand its trials to include additional autoimmune diseases, which could broaden the market for FT819 significantly. Fate’s pipeline doesn’t stop with FT819. The company is also advancing other therapies, like FT825 and FT522, which target different types of cancers. FT825 is designed to treat solid tumors, while FT522 focuses on blood cancers. Like FT819, these therapies aim to simplify the treatment process by avoiding the need for chemotherapy conditioning. FT522, for example, uses natural killer (NK) cells to target B-cell cancers, offering a promising new way to treat patients with difficult-to-treat cancers. On the financial side, Fate Therapeutics is well-funded, with $307 million in cash and investments at the end of 2024. This gives the company plenty of resources to continue advancing its clinical programs, and the company’s strong partnerships with firms like Ono Pharmaceutical further enhance its growth potential. With its innovative approach to off-the-shelf stem cell therapies, Fate Therapeutics is positioning itself as a leader in the field. Its therapies for autoimmune diseases and cancer are showing real promise, and with strong financial backing, the company is poised for continued progress in the years ahead. Mesoblast Limited (NASDAQ: MESO) is a global leader in developing allogeneic (off-the-shelf) cellular medicines for the treatment of severe, life-threatening inflammatory diseases. The company's therapies leverage its proprietary mesenchymal stromal cell (MSC) technology, which works by releasing anti-inflammatory factors to help modulate the immune system and reduce harmful inflammation. This technology is aimed at addressing conditions like steroid-refractory acute graft-versus-host disease (SR-aGvHD) and chronic heart failure, among others. Mesoblast's FDA-approved product, Ryoncil (remestemcel-L), is the first MSC-based therapy to gain approval for the treatment of pediatric patients with SR-aGvHD, a life-threatening condition that occurs after bone marrow transplants. In December 2024, the U.S. FDA approved Ryoncil for use in children as young as two months old, marking a significant milestone for the company. The therapy has demonstrated strong clinical results, with a 70% overall response rate in a Phase 3 trial and a survival rate of 49% at four years for children treated with Ryoncil. The company is also working on expanding Ryoncil’s applications to other inflammatory diseases, such as adult SR-aGvHD and biologic-resistant inflammatory bowel disease (IBD). Furthermore, Mesoblast is advancing its second key product, Rexlemestrocel-L (Revascor), which is being studied for chronic heart failure and chronic low back pain. These treatments offer promising alternatives to existing therapies by addressing the underlying inflammation that often complicates these diseases. In terms of growth and financial stability, Mesoblast has been proactive in securing strategic partnerships and expanding its market presence. The company has agreements in key regions such as Japan, Europe, and China. Additionally, it has an extensive intellectual property portfolio, with over 1,000 granted patents covering MSC compositions, manufacturing methods, and therapeutic indications. Financially, Mesoblast is in a strong position, with a cash balance of $38 million at the end of 2024. The company raised an additional $161 million in a private placement, which bolsters its ability to continue advancing its research and development initiatives. Mesoblast’s CEO, Dr. Silviu Itescu, expressed his enthusiasm about the future, noting, "Our FDA-approved product Ryoncil will be available in the coming weeks to children with SR-aGvHD in need of life-saving therapy." Overall, Mesoblast’s strong pipeline of therapies and its leadership in the allogeneic cell medicine space position it as a promising company in the stem cell and regenerative medicine sectors. With its recent FDA approval and expanding commercial partnerships, Mesoblast is set to make a significant impact in treating inflammatory diseases globally. CRISPR Therapeutics (NASDAQ: CRSP) is a pioneer in gene editing, making history as the first company to bring a CRISPR-based therapy to market. The company’s flagship product, CASGEVY, was approved in multiple countries in late 2023 to treat sickle cell disease (SCD) and transfusion-dependent beta-thalassemia (TDT)—two serious genetic blood disorders. Since then, patient demand has been strong, with over 50 authorized treatment centers (ATCs) worldwide and more than 50 patients having initiated cell collection by the end of 2024. Looking ahead, 2025 is shaping up to be a big year for CRISPR Therapeutics. The company is working on next-generation gene-editing programs and expanding into new disease areas like oncology, autoimmune disorders, and cardiovascular diseases. CEO Samarth Kulkarni called 2025 a "milestone-rich year" with major clinical updates expected across the company’s pipeline. While CASGEVY’s commercial rollout continues, CRISPR Therapeutics is making progress on several other fronts. CTX112 is a next-generation CAR T-cell therapy for blood cancers and autoimmune diseases. Early results showed strong efficacy in lymphoma patients, earning it a Regenerative Medicine Advanced Therapy (RMAT) designation from the FDA. In cardiovascular disease, CTX310 and CTX320 are experimental therapies targeting cholesterol and lipoprotein(a), a genetic risk factor for heart disease. Clinical updates are expected in the first half of 2025. CTX211 is a gene-edited stem cell therapy for Type 1 diabetes (T1D), designed to free patients from insulin injections without needing long-term immune suppression. CRISPR Therapeutics ended 2024 with $1.9 billion in cash and investments, giving it a strong financial cushion to fund research and commercialization efforts. The company has also partnered with Vertex Pharmaceuticals on CASGEVY, benefiting from Vertex’s commercial expertise as they roll out the therapy globally. Disclaimers: RazorPitch Inc. "RazorPitch" is not operated by a licensed broker, a dealer, or a registered investment adviser. This content is for informational purposes only and is not intended to be investment advice. The Private Securities Litigation Reform Act of 1995 provides investors a safe harbor in regard to forward-looking statements. Any statements that express or involve discussions with respect to predictions, expectations, beliefs, plans, projections, objectives, goals, assumptions, or future events or performances are not statements of historical fact and may be forward-looking statements. Forward-looking statements are based on expectations, estimates, and projections at the time the statements are made that involve a number of risks and uncertainties that could cause actual results or events to differ materially from those presently anticipated. Forward-looking statements in this action may be identified through the use of words such as projects, foresee, expects, will, anticipates, estimates, believes, understands, or that by statements indicating certain actions & quote; may, could, or might occur. Understand there is no guarantee past performance will be indicative of future results. Investing in micro-cap and growth securities is highly speculative and carries an extremely high degree of risk. It is possible that an investor's investment may be lost or impaired due to the speculative nature of the companies profiled. RazorPitch has been retained and compensated by ADIA to assist in the production and distribution of this content. RazorPitch is responsible for the production and distribution of this content. It should be expressly understood that under no circumstances does any information published herein represent a recommendation to buy or sell a security. This content is for informational purposes only; you should not construe any such information or other material as legal, tax, investment, financial, or other advice. Nothing contained in this article constitutes a solicitation, recommendation, endorsement, or offer by RazorPitch or any third-party service provider to buy or sell any securities or other financial instruments. All content in this article is information of a general nature and does not address the circumstances of any particular individual or entity. Nothing in this article constitutes professional and/or financial advice, nor does any information in the article constitute a comprehensive or complete statement of the matters discussed or the law relating thereto. RazorPitch is not a fiduciary by virtue of any persons use of or access to this content. Contact Details RazorPitch Mark McKelvie +1 585-301-7700 mark@razorpitch.com Company Website http://razorpitch.com

April 02, 2025 07:00 AM Eastern Daylight Time

Mid-Sized Data Centers Are Winning the Communications Battle While Many Industry Leaders Fall Behind

Hot Paper Lantern

Hot Paper Lantern (HPL), an integrated communications and marketing agency that helps brands build their reputations, create meaningful impact, and generate growth, released its latest data center industry study, "Who's Owning the Conversation?" The study analyzed over 35 companies spanning three key verticals: data center operators, cooling technology vendors, and network service providers. Data Center Operators included in the study: Aligned Data Centers • CloudHQ • Cologix • Compass Datacenters • COPT • CoreSite • DataBank • Digital Core REIT • EdgeConneX • Evoque Data Center Solutions • Flexential • OVHcloud • QTS Data Centers • Sabey Data Centers • STACK Infrastructure • Switch Inc. • Tencent Cloud • Vantage Data Centers Cooling Technology Vendors included in the study: Amana Heating & Air • American Standard • Bryant Heating & Cooling • Goodman Manufacturing • Heil Heating & Cooling • Nortek Global • Rheem • Rudd Heating & Cooling • York Air Conditioning • York International Network Service Providers included in the study: Adtran • Allied Telesis • Calix • Cambium Networks • D-Link • Inseego • MikroTik • TP-Link • Viavi Solutions • Zyxel Communications The research examines how these companies are shaping the mid-market narrative, identifies key areas for improvement, and offers data-driven strategies to help companies drive meaningful engagement. While some organizations take a proactive approach to their external communications by leveraging social media and media relations, others remain passive and allow third parties to shape their company’s narrative. This contrast sparks critical questions about how key sectors engage with their stakeholders and whether or not they will fully capitalize on the opportunities presented by the data center industry's unprecedented growth. "Data center operators have assumed that by just being active to generate some form of media coverage alone, this will translate to having a strong reputation. Our research proves that this is not the case. If you are not actively shaping your own story, someone else will do it for you, and often not in your favor," said Ed Moed, chief executive officer at Hot Paper Lantern. "The data center industry has grown exponentially in recent years, fueled by massive investments, technological advancement, and industry demand. Many companies have relied on that growth to define their value in the market, but as competition increases, a strong and strategic narrative is what will set organizations apart." Key Insights from the Study: Public Perception Doesn't Always Align with Coverage Volume – More coverage does not always translate to a stronger reputation. Nearly 10% of all social media conversations about the data center industry are negative. However, over 80% of that negativity comes from just two companies, and both are among the most active on social media. Their outsized presence has amplified criticism, highlighting the risks of lacking a strategic online narrative. Mid-Tier Operators Punch Above Their Weight in Influence — Despite having smaller budgets, some mid-tier data centers generate outsized impact. Based on revenue, the bottom half of companies analyzed averaged 7x more coverage and 15x more engagement, demonstrating the power of strategic messaging. Cooling Technology Vendors Are Missing Their Storytelling Opportunity — With sustainability and energy efficiency becoming critical topics, cooling providers remain surprisingly underrepresented in industry conversations. Ninety percent of cooling brands generate fewer than 500 media mentions across major platforms, creating a massive opportunity for those willing to participate in the discussion. Network Providers Are Failing to Engage the Data Center Audience — Despite playing a crucial role in data center operations, many network providers struggle to connect with their target audience. Most rely on generic product announcements rather than crafting narratives that will resonate with data center decision-makers. As a result, the top 40% of network providers account for 95% of the industry's digital visibility, leaving the majority with little influence in the conversation. "Cooling and network providers have expanded alongside the data center industry, yet their voice in industry discussions has not kept pace," said Moed. "As artificial intelligence accelerates demand for advanced infrastructure, these sectors must step forward. The companies that fail to establish themselves as industry leaders risk being overlooked, while those that actively shape the conversation will define the next phase of innovation and growth." For more details on the "Who's Owning the Conversation?" study, view the report here. HPL will continue tracking industry trends and key players, releasing quarterly reports about the evolving conversation. To stay informed on the latest findings and updates, visit www.hotpaperlantern.com and sign up for future reports. Hot Paper Lantern (HPL) is a New York City-based integrated communications and marketing agency that helps brands build their reputations, create meaningful impact, and generate growth. HPL partners with clients to find, engage, and form deeper connections with key audiences and stakeholders. For more information, visit www.hotpaperlantern.com. Contact Details Hot Paper Lantern emoed@hotpaperlantern.com Company Website https://hotpaperlantern.com/

April 01, 2025 10:00 AM Eastern Daylight Time

UNOS adds two members to its board of directors

United Network for Organ Sharing

Today, the United Network for Organ Sharing (UNOS) announced that its Board of Directors has unanimously approved two new board members, bringing the board complement to nine. Melina Davis and Mark Johnson will begin their terms on April 1, 2025, serving until September 30, 2028. They were approved by a full board vote on March 24. “I’m pleased to welcome Melina and Mark to the UNOS Board of Directors,” said Sue Dunn, chair of the UNOS board of directors. “They each have an incredible background that exemplifies UNOS’ strategic priorities and work to help save and improve lives.” Davis and Johnson bring decades of executive leadership to the UNOS Board of Directors, both within and outside of healthcare. Davis is the CEO and executive vice president of the Medical Society of Viriginia and Johnson is the former CEO of Averhealth and BetterMed Urgent Care. “I’m honored to join the UNOS Board of Directors. UNOS is an organization that’s committed to enhancing the lives and health of individuals. Together, with my fellow board members, I will advocate for innovative solutions, enhance donor awareness, and strive to improve the overall donation and transplant system,” said Davis. “By collaborating, we can advance our goal to give hope and a second chance to many individuals and their families. I look forward to engaging with the community and harnessing our collective expertise to drive meaningful change.” “It’s an honor to be appointed to the UNOS Board of Directors, and for the opportunity to work with UNOS’ CEO Maureen McBride and the UNOS team as they pursue strategic initiatives to provide critical, high-value organ sharing and transplant services,” said Johnson. “As the complex organ transplantation system undergoes change, UNOS’ breadth and depth of know-how, and its extensive relationships with transplant hospitals and other stakeholders, point to a bright future for UNOS and for the many patients who rely on critical organ donations. I look forward to contributing strategic, financial and capital deployment support to UNOS as it advances its mission.” Davis and Johnson join UNOS’ current seven-member board, whose term began on March 30, 2024: Sue Dunn, former CEO of Donor Alliance Bapu Jena, M.D., Ph.D., professor of health care policy at Harvard Medical School, internist at Massachusetts General Hospital Maryl Johnson, M.D., professor at the University of Wisconsin School of Medicine Irene Kim, M.D., director of the Comprehensive Transplant Center at Cedars-Sinai Jake Kouns, founder of RVAsec James Pittman, assistant vice president of transplant and dialysis services for HCA Healthcare Marie Quintero-Johnson, retired vice president of corporate development for Coca-Cola and kidney recipient About UNOS The United Network for Organ Sharing (UNOS) is a nonprofit organization that serves the organ donation and transplant system and broader public health community through its work developing new technologies and initiatives, conducting data-driven research and analysis, providing expert consulting services, advocating for patients, and being a leader in bringing communities together to save lives. Contact Details United Network for Organ Sharing Anne Paschke anne.paschke@unos.org Company Website https://unos.org

March 31, 2025 02:01 PM Eastern Daylight Time

Market Alert: Palatin's Disruptive Obesity Drug Combination Shows Groundbreaking Weight Loss Results in Phase 2 Topline Data (NYSE: PTN)

Global Markets News

Palatin Technologies* has unveiled compelling topline results from its Phase 2 study showing that patients receiving its obesity drug bremelanotide in combination with tirzepatide achieved a 4.4% weight reduction compared to just 1.6% for placebo—a highly statistically significant difference (p<0.0001). The eight-week trial demonstrated that combining these two mechanisms creates a synergistic effect, with 40% of patients in the combination group achieving at least 5% weight loss compared to 27% with tirzepatide alone. The economic potential of anti-obesity drugs is enormous, with the market expected to reach US$100 billion by 2030. As obesity rates continue to climb globally, with the number of obese individuals worldwide projected to increase from 980 million to nearly 2 billion from 2022 to 2035, innovative treatment approaches like Palatin's are positioning themselves in this rapidly expanding market. Perhaps most intriguing for the obesity treatment landscape, Palatin's data revealed that its drug effectively halted the rapid weight regain typically seen after stopping GLP-1/GIP therapy. This addresses one of the most significant challenges facing current obesity treatments, where patients often regain substantial weight after discontinuation. The economic potential of anti-obesity drugs is enormous, with the market expected to reach US$100 billion by 2030. As obesity rates continue to climb globally, with the number of obese individuals worldwide projected to increase from 980 million to nearly 2 billion from 2022 to 2035, innovative treatment approaches like Palatin's are positioning themselves in this rapidly expanding market. Palatin is advancing development of next-generation long-acting injectable and oral versions of its obesity compounds, with investigational new drug applications planned for late 2025 and clinical data expected in early 2026. The company is one of just two developing therapies targeting this specific biological pathway for obesity. This announcement follows recent positive news from Palatin's ulcerative colitis program and FDA orphan drug designation for its oral obesity compound for rare genetic obesity disorders, demonstrating the company's momentum across multiple therapeutic areas with significant unmet needs. Subscribe For More Alerts: https://newsletter.page/wallstreetalerts Recent Palatin Technologies News Highlights: Palatin Announces Positive Topline Results from Phase 2 Ulcerative Colitis (UC) Study of Oral Melanocortin-1 Receptor Agonist PL8177 Completion of Phase 2 Obesity Study With MC4R Bremelanotide Plus GLP-1/GIP Tirzepatide Palatin Announces Positive Phase IIb BREAKOUT Study Results in Patients with Type 2 Diabetic Nephropathy Palatin Announces Completion of Patient Enrollment in Phase 2 Study of Orally Administered Melanocortin Agonist PL8177 in Ulcerative Colitis *DISCLAIMER: This alert is published by Wall Street Wire. Wall Street Wire does not provide financial or investment advice, and our content does not represent an offer to buy or sell securities. Wall Street Wire is a promotional content brand and its operators are not registered brokers, dealers, or investment advisers. This alert contains and is a form of paid promotional content for to Palatin Technologies and was produced as part of their paid subscription to Wall Street Wire’s distribution and promotional content services. This alert has not been reviewed or approved by Palatin Technologies prior to publication. Please review the full disclaimers and compensation disclosures here: redditwire.com/terms Contact Details Wall Street Wire Market Aerts Desk media.globalmarkets@gmail.com

March 31, 2025 09:19 AM Eastern Daylight Time

Market Alert: Inspira Technology Gains Industry Exposure as FDA-Cleared Technology Showcased at Major Conference

Global Markets News

Market News Alerts Reports: Inspira Technologies (NASDAQ: IINN)* is gaining attention today as their FDA-cleared INSPIRA™ ART100 life-support system is being showcased at the prestigious AmSECT International Conference in San Diego, potentially exposing their technology to hundreds of perfusion professionals. This high-profile exhibition comes at a strategic moment for Inspira, with recent developments showing momentum: The FDA-cleared INSPIRA ART100 system is being prepared for deployment in leading U.S. hospitals Recent clinical studies demonstrated 96% accuracy for their HYLA blood sensor technology The company is advancing development of their flagship INSPIRA ART500 system With the company visionairy approach targeting approximately 20 million ICU patients with acute respiratory failure annually worldwide, Inspira aims to address significant markets: the $5.7B blood gas analyzer market and the $19B mechanical ventilation sector. The company's approach allows patients to remain awake during treatment without ventilators—addressing a need where current solutions face significant challenges. This conference appearance raises Inspira's profile within the perfusion community, potentially supporting their commercialization strategy as they work to introduce their technology to medical institutions. * Disclaimer: Nothing in this report constitutes financial or investment advice, nor does it represent an offer to buy or sell securities. This report is published Market News Alerts Research, a promotional content brand which is part of the Wall Street Wire™ network. The operators of Wall Street Wire are not registered brokers, dealers, or investment advisers. This distribution contains paid promotional content related to Inspira Technologies and was produced as part of their paid subscription to Wall Street Wire. This report has not been reviewed or approved by Inspira prior to publication. Please review the full disclaimers and compensation disclosures here: redditwire.com/terms. Contact Details Markets News Alerts Editorial Desk globalmarkets.media@gmail.com

March 19, 2025 11:28 AM Eastern Daylight Time